Influence of vitamin D and retinoids on the induction of functional differentiation in vitro of canine osteosarcoma clonal cells.

@article{Barroga2000InfluenceOV,
  title={Influence of vitamin D and retinoids on the induction of functional differentiation in vitro of canine osteosarcoma clonal cells.},
  author={E F Barroga and Tsuyoshi Kadosawa and Masahiro Okumura and Toru Fujinaga},
  journal={Veterinary journal},
  year={2000},
  volume={159 2},
  pages={
          186-93
        }
}
The efficacy of 22-oxacalcitriol (OCT), calcitriol, cholecalciferol, all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA) to differentiate in vitro four clonal cells of the canine osteosarcoma cell line POS into cells having properties of a functionally mature osteoblast bone cell were investigated. The induction of intracellular alkaline phosphatase (ALP) activity, osteocalcin (GLA-OC) and type I collagen (PIP) production after 72 h treatment were used as markers of… CONTINUE READING

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