Influence of viscosity on absorption from nitrofurantoin suspensions.

  title={Influence of viscosity on absorption from nitrofurantoin suspensions.},
  author={M M Soci and Emma L Parrott},
  journal={Journal of pharmaceutical sciences},
  volume={69 4},
Nitrofurantoin, 200 mg, was administered orally to 11 subjects in an aqueous reference dispersion and in five suspensions having the same rheogram. Algin, carbomer, guar gum, methylcellulose, and colloidal magnesium aluminum silicate were the five suspending agents employed. Complexation was demonstrated by dialysis between nitrofurantoin and methylcellulose and between nitrofurantoin and carbomer; however, physiological availability was not altered by the interaction. The viscosity increase… CONTINUE READING