Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers

Abstract

Oxcarbazepine (OXC), a second-generation antiepileptic, and its chiral metabolite 10-hydroxycarbazepine (MHD) are substrates of P-glycoprotein, which can be inhibited by verapamil. This study evaluated the influence of verapamil on the pharmacokinetics of OXC and MHD enantiomers in healthy volunteers. Healthy volunteers (n = 12) on occasion O (OXC… (More)
DOI: 10.1007/s00228-015-1970-4

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@article{Antunes2015InfluenceOV, title={Influence of verapamil on the pharmacokinetics of oxcarbazepine and of the enantiomers of its 10-hydroxy metabolite in healthy volunteers}, author={Natal{\'i}cia de Jesus Antunes and Lauro Wichert-Ana and Eduardo Coelho and Oscar E Della Pasqua and Veriano Alexandre J{\'u}nior and Osvaldo Massaiti Takayanagui and Eduardo Tozatto and Maria Paula M. Marques and Vera L{\'u}cia Lanchote}, journal={European Journal of Clinical Pharmacology}, year={2015}, volume={72}, pages={195-201} }