Influence of vasostatins, the chromogranin A-derived peptides, on the working heart of the eel (Anguilla anguilla): negative inotropy and mechanism of action.

@article{Imbrogno2004InfluenceOV,
  title={Influence of vasostatins, the chromogranin A-derived peptides, on the working heart of the eel (Anguilla anguilla): negative inotropy and mechanism of action.},
  author={Sandra Imbrogno and Tommaso Angelone and Angelo Corti and Cristina Adamo and Karen B. Helle and Bruno Tota},
  journal={General and comparative endocrinology},
  year={2004},
  volume={139 1},
  pages={20-8}
}
We have studied the effects of exogenous human recombinant Vasostatin-1 (VS-1), Vasostatin-2 (VS-2) and the human Chromogranin A (CGA) 7-57 synthetic peptides on the mechanical performance of the isolated and perfused working eel (Anguilla anguilla) heart. Under basal conditions, the three peptides decreased stroke volume (SV) and stroke work (SW), thus exerting negative inotropism. The VS-1-mediated negative inotropism was abolished by exposure to inhibitors of either Gi/o protein (pertussis… CONTINUE READING

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