Influence of various doses of aspirin (in vivo) on platelet arachidonic acid metabolism (ex vivo) and function.

@article{Rao1994InfluenceOV,
  title={Influence of various doses of aspirin (in vivo) on platelet arachidonic acid metabolism (ex vivo) and function.},
  author={G. Rao and J. White},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1994},
  volume={51 1},
  pages={
          63-7
        }
}
  • G. Rao, J. White
  • Published 1994
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty acids
    • The influence of various doses of enteric-coated aspirin was evaluated for its in vivo effect on ex vivo platelet arachidonic acid metabolism and function. 24 h after ingestion of the drugs compromised platelet response to the action of agonists such as epinephrine and arachidonate could be demonstrated with as low a dose as 50 mgs aspirin. However, platelets with compromised function were still capable of producing significant quantities of thromboxane. On the other hand, platelets with almost… CONTINUE READING
    View on PubMed
    doi.org
    7 Citations

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    7 Citations
    Citation Type

    Citation Type

    A randomized, placebo-controlled, crossover study of E5510 and aspirin in healthy volunteers.
    • 2
    Platelet Physiology and Pharmacology: An Overview
    • 4
    In‐vitro and Ex‐vivo Inhibition of Blood Platelet Aggregation by Naftazone
    • 10
    Synergistic effect of D-003 and aspirin on experimental thrombosis models.
    • 16
    Platelet Arachidonic Acid Deficiency May Contribute to Abnormal Platelet Function During Parenteral Fish Oil Monotherapy in a Piglet Model.
    • 17
    Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers.
    • 38
    FarmacologÌa de los agentes antiagregantes plaquetarios
    • 3
    • PDF

    References

    SHOWING 1-10 OF 26 REFERENCES
    Influence of low dose enteric-coated aspirin on platelet function.
    • 2
    Low dose aspirin, platelet function and prostaglandin synthesis: influence of epinephrine and alpha adrenergic blockade.
    • 22
    Influence of epinephrine on the aggregation response of aspirin-treated platelets.
    • 83
    Effect of Chronic Low Dose Aspirin on Platelet and Vascular Eicosanoid Metabolism in Nonhuman Primates (Macaca fascicularis)
    • 8
    Why single daily dose of aspirin may not prevent platelet aggregation.
    • 16
    A regimen for low-dose aspirin?
    • 53
    • PDF
    Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients.
    • 441
    Rapid return of cyclo-oxygenase active platelets in dogs after a single oral dose of aspirin.
    • 30
    Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin.
    • 244
    Cumulative antiplatelet effect of low‐dose enteric coated aspirin
    • 95