Influence of vaccination-challenge interval on the protective efficacy of bacille Calmette-Guérin against low-virulence Mycobacterium tuberculosis.

The influence of vaccination-infection interval on protection induced by bacille Calmette-Guérin (BCG) was studied in an animal model of experimental airborne tuberculosis. Guinea pigs were simultaneously skin-tested with mammalian tuberculin and intracellularin and vaccinated with BCG-Copenhagen (strain no. 1331). At weekly intervals thereafter, groups of… CONTINUE READING