Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation.

@article{Loeffler1992InfluenceOT,
  title={Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation.},
  author={David A. Loeffler and Paul L. Juneau and S. Masserant},
  journal={British Journal of Cancer},
  year={1992},
  volume={66},
  pages={619 - 622}
}
The proliferative response of murine lymphocytes to interleukin-2 (IL-2) was examined under physico-chemical conditions present in solid tumours, namely low oxygen and glucose concentrations and acidic pH. Lymphocytes were cultured for four days in 30 U ml-1 IL-2 to simulate serum IL-2 concentrations attainable with high-dose systemic IL-2 therapy. Lymphocyte proliferation was significantly (P < 0.05) reduced by low oxygen concentrations (both anoxia [0% O2] and hypoxia [10%, low glucose (6 mg… CONTINUE READING

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How safe is interleukin - 2 ? Combined results from 2034 patients

  • A. LOUIE, D. CARLIN, E. BRADLEY
  • Proc . Am . Soc . Clin . Oncol .
  • 1989
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