Influence of trifluoperazine on platelet aggregation and disaggregation.

@article{Rao1980InfluenceOT,
  title={Influence of trifluoperazine on platelet aggregation and disaggregation.},
  author={G. Rao and K. Reddy and J. White},
  journal={Prostaglandins and medicine},
  year={1980},
  volume={5 3},
  pages={
          221-34
        }
}
  • G. Rao, K. Reddy, J. White
  • Published 1980
  • Chemistry, Medicine
  • Prostaglandins and medicine
    • Calmodulin has been shown to activate platelet phospholipase A2 and initiate the metabolism of arachidonic acid. Trifluoperazine (stelazine), an agent which selectively binds calmodulin, inhibits phospholipase activity induced by calcium. We have evaluated the effect of this agent on the aggregation, disaggregation and reaggregation of human platelets. Results of our study have shown that stelazine is a selective inhibitor of the second wave response of platelets to the stimulation of agonists… CONTINUE READING
    View on PubMed
    doi.org
    31 Citations
    Background Citations
    4
    Methods Citations
    1
    Results Citations
    1
    31 Citations
    Citation Type

    Citation Type

    Effects of trifluoperazine on platelet activation.
    • 3
    Role of arachidonic acid metabolism in human platelet activation and irreversible aggregation
    • 24
    Influence of calmodulin antagonist (stelazine) on agonist-induced calcium mobilization and platelet activation.
    • G. Rao
    • Chemistry, Medicine
    • Biochemical and biophysical research communications
    • 1987
    • 8
    Differential effects of trifluoperazine on arachidonate liberation, secretion and myosin phosphorylation in intact platelets.
    • 27
    Influence of a calcium dependent protease inhibitor on platelet activation and secretion.
    • 11
    Phenothiazines inhibit collagen-induced thromboxane B2 synthesis and increase forskolin anti-aggregating effects in human platelets.
    • 6
    Platelet aggregation independent of ADP release or prostaglandin synthesis in patients with hermansky-Pudlak syndrome.
    • 34
    Mechanism of vasopressin-induced platelet aggregation.
    • 67
    Mechanism of PAF-induced platelet aggregation in man.
    • 32
    Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents
    • 17

    References

    SHOWING 1-10 OF 45 REFERENCES
    The influence of epinephrine on prostacyclin (PGI2) induced dissociation of ADP aggregated plateletes.
    • 37
    Effects of the lonophore A23187 on blood platelets I. Influence on aggregation and secretion.
    • 156
    Interference of bromophenacyl bromide with platelet phospholipase A2 activity induced by thrombin and by the ionophore A23187.
    • 25
    Carrageenan and thrombin trigger prostaglandin synthetase‐independent aggregation of rabbit platelets: inhibition by phospholipase A2 inhibitors *
    • B. Vargaftig
    • Medicine, Chemistry
    • The Journal of pharmacy and pharmacology
    • 1977
    • 83
    Platelet secretion induced by divalent cation ionophores
    • 186
    Inhibition of Adenosine Diphosphate-Induced Secondary Aggregation and Other Platelet Functions by Acetylsalicylic Acid Ingestion∗
    • M. Zucker, J. Peterson
    • Chemistry, Medicine
    • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
    • 1968
    • 308
    A method for investigating the role of calcium in the shape change, aggregation and serotonin release of rat platelets.
    • 23
    Cyclic AMP and platelet prostaglandin synthesis.
    • 91
    Cyclic adenosine 3',5'-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets.
    • 181
    Regulation of platelet phosphorylase.
    • 19