Influence of trifluoperazine on platelet aggregation and disaggregation.

  title={Influence of trifluoperazine on platelet aggregation and disaggregation.},
  author={G. Rao and K. Reddy and J. White},
  journal={Prostaglandins and medicine},
  volume={5 3},
  • G. Rao, K. Reddy, J. White
  • Published 1980
  • Chemistry, Medicine
  • Prostaglandins and medicine
  • Calmodulin has been shown to activate platelet phospholipase A2 and initiate the metabolism of arachidonic acid. Trifluoperazine (stelazine), an agent which selectively binds calmodulin, inhibits phospholipase activity induced by calcium. We have evaluated the effect of this agent on the aggregation, disaggregation and reaggregation of human platelets. Results of our study have shown that stelazine is a selective inhibitor of the second wave response of platelets to the stimulation of agonists… CONTINUE READING
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