Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.

@article{Prieto2003InfluenceOT,
  title={Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.},
  author={J M Prieto and M Carmen Recio and Rosa Marfa Giner and Salvador M{\'a}{\~n}ez and Eva M Giner-Larza and Jos{\'e} P{\'e}rez R{\'i}os},
  journal={The Journal of pharmacy and pharmacology},
  year={2003},
  volume={55 9},
  pages={1275-82}
}
The enzymes 5-lipoxygenase and elastase are therapeutic targets in dermatological disorders such as psoriasis. Fifteen extracts from traditional Chinese medicinal plants used to treat topical inflammations were screened for their inhibitory effect on lipoxygenase, cyclooxygenase and elastase activity in intact leukocytes and platelets. Astragalus membranaceus, Forsythia suspensa and Poria cocos inhibited 5-lipoxygenase, with IC50 values of 141, 80 and 141 microg mL(-1), respectively. The latter… CONTINUE READING