Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.

@article{Kurz2004InfluenceOT,
  title={Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression.},
  author={Bodo Kurz and Angelika K. Lemke and Melanie Kehn and Christian Domm and Parth Patwari and Eliot H. Frank and Alan J. Grodzinsky and Michael Schuenke},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 1},
  pages={123-30}
}
OBJECTIVE To study the influence of tissue maturation and antioxidants on apoptosis in bovine articular cartilage induced by injurious compression. METHODS Bovine articular cartilage disks were obtained from the femoropatellar groove of animals ages 0.5-23 months and placed in culture. Cartilage disks were preincubated overnight with the cell-permeable superoxide dismutase (SOD) mimetic Mn(III) porphyrin (0-12.5 microM) or alpha-tocopherol (0-50 microM) and then injured by a single unconfined… CONTINUE READING

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