Influence of third-generation cephalosporins on aerobic intestinal flora.

@article{Guggenbichler1984InfluenceOT,
  title={Influence of third-generation cephalosporins on aerobic intestinal flora.},
  author={Josef Peter Guggenbichler and Johann Kofler},
  journal={The Journal of antimicrobial chemotherapy},
  year={1984},
  volume={14 Suppl B},
  pages={67-70}
}
Excretion of an antibiotic in bile may result in high intra-intestinal concentrations and thus alteration in the faecal flora. We investigated the effects of cefoperazone (75% biliary excretion), ceftriaxone (45%) and cefotaxime (5%) on the aerobic faecal flora. Cefoperazone reduced numbers of normal Gram-negative bacilli and selected resistant Pseudomonas… CONTINUE READING