Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.

@article{Yoshida2008InfluenceOT,
  title={Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.},
  author={Keizo Yoshida and Hisashi Higuchi and Hitoshi Takahashi and Mitsuhiro Kamata and Kazuhiro Sato and Kazuyuki Inoue and Toshio Suzuki and Kunihiko Itoh and Norio Ozaki},
  journal={Human psychopharmacology},
  year={2008},
  volume={23 2},
  pages={121-8}
}
OBJECTIVE Genetic polymorphisms of the noradrenergic pathway can be factors to predict the effect of antidepressants when their pharmacological mechanisms of action include the noradrenergic system. The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor. METHOD Eighty-one Japanese… CONTINUE READING

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