Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain.

@article{Kreuter2004InfluenceOT,
  title={Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain.},
  author={Joerg Kreuter},
  journal={Journal of nanoscience and nanotechnology},
  year={2004},
  volume={4 5},
  pages={484-8}
}
  • Joerg Kreuter
  • Published 2004 in Journal of nanoscience and nanotechnology
Poly(alkyl cyanoacrylate) nanoparticles enable the delivery of a number of drugs, including doxorubicin, loperamide, tubocurarine, the NMDA receptor antagonist MRZ 2/576, and the peptides dalargin and kytorphin across the blood-brain barrier (BBB) after coating with surfactants. However, only the surfactants polysorbate (Tween) 20, 40, 60 and 80, and some poloxamers (Pluronic F 68) can induce this uptake. The mechanism for the delivery across the BBB most likely is endocytosis via the LDL… CONTINUE READING
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