Influence of the substitution of 11-methylene, Δ15, and/or 18-methyl groups in norethisterone on receptor binding, transactivation assays and biological activities in animals

@article{Deckers2000InfluenceOT,
  title={Influence of the substitution of 11-methylene, Δ15, and/or 18-methyl groups in norethisterone on receptor binding, transactivation assays and biological activities in animals},
  author={G. Deckers and W. Schoonen and H. Kloosterboer},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2000},
  volume={74},
  pages={83-92}
}
  • G. Deckers, W. Schoonen, H. Kloosterboer
  • Published 2000
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • The profile of norethisterone and newly developed derivatives thereof were assessed by in vitro binding and transactivation assays on progesterone (PR) as well as on androgen (AR) receptors and by subcutaneous treatment in in vivo models. The following in vivo models were performed: A McPhail test for progestational activity in immature rabbits, an ovulation inhibition test in cycling rats and a Hershberger test for androgenic activity in immature orchidectomised rats. The compounds tested were… CONTINUE READING

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