Influence of the spleen on the expression of surface antigens on parasitized erythrocytes.

@article{Barnwell1983InfluenceOT,
  title={Influence of the spleen on the expression of surface antigens on parasitized erythrocytes.},
  author={John W. Barnwell and Russell J. Howard and Louis H. Miller},
  journal={Ciba Foundation symposium},
  year={1983},
  volume={94},
  pages={117-36}
}
Two malaria parasites, Plasmodium knowlesi and P. falciparum, when passaged in splenectomized hosts alter or fail to express parasite-dependent antigens on the surface membrane of erythrocytes infected with mature parasites. Experiments with cloned populations of P.knowlesi show this change to be phenotypic and to be modulated by the spleen of the host. In addition, the induction of antigen variation in P. knowlesi malaria apparently requires two factors: specific antibody and the spleen. Along… CONTINUE READING

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