Influence of the route of glucose administration on hepatic glycogen repletion.

@article{Shulman1989InfluenceOT,
  title={Influence of the route of glucose administration on hepatic glycogen repletion.},
  author={Gerald I Shulman and Luciano Rossetti},
  journal={The American journal of physiology},
  year={1989},
  volume={257 5 Pt 1},
  pages={E681-5}
}
To delineate the role of the route of glucose administration on liver glycogen synthesis, we administered [1-13C]glucose either by intravenous or intraduodenal infusion to chronically catheterized 24-h fasted rats and performed 1) intravenous-hyperglycemic clamp (group I, n = 9), portal vein plasma glucose and insulin concentrations were 216 +/- 6 mg/dl and 23.9 +/- 4.2 ng/ml; 2) intraduodenal-hyperglycemic infusion (group II, n = 8), portal vein glucose and insulin concentrations were 219… CONTINUE READING

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