Influence of the route of administration on the mean hepatic extraction ratio of propranolol in the rat.

Abstract

The mean hepatic extraction ratio (ER) of propranolol was estimated directly by simultaneous measurements of arterial and hepatic venous blood concentrations of the drug following systemic venous and portal venous administration in the rat. The ER was greater than 0.9 in the dose range of 2.5 to 12.5 mg/kg following rapid infusion of propranolol into the… (More)

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@article{Suzuki1980InfluenceOT, title={Influence of the route of administration on the mean hepatic extraction ratio of propranolol in the rat.}, author={T Suzuki and Shuji Isozaki and Tsuneo Ohkuma and Tadaaki Rikihisa}, journal={Journal of pharmacobio-dynamics}, year={1980}, volume={3 11}, pages={603-11} }