Influence of the route of administration on immunomodulatory properties of bovine beta-lactoglobulin-producing Lactobacillus casei.

@article{Hazebrouck2009InfluenceOT,
  title={Influence of the route of administration on immunomodulatory properties of bovine beta-lactoglobulin-producing Lactobacillus casei.},
  author={St{\'e}phane Hazebrouck and Laetitia Przybylski-Nicaise and Sandrine Ah-Leung and Karine Adel-Patient and G{\'e}rard Corthier and Philippe Langella and J M Wal},
  journal={Vaccine},
  year={2009},
  volume={27 42},
  pages={5800-5}
}
Because of their intrinsic immunomodulatory properties, some lactic acid bacteria were reported to modulate allergic immune responses in mice and humans. We recently developed recombinant strains of Lactobacillus casei that produce beta-lactoglobulin (BLG), a major cow's milk allergen. Here, we investigated immunomodulatory potency of intranasal and oral administrations of recombinant lactobacilli on a subsequent sensitization of mice to BLG. Intranasal administration of the BLG-producing Lb… CONTINUE READING

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