Influence of the oral administration of excess copper on the immune response.

@article{Pocino1991InfluenceOT,
  title={Influence of the oral administration of excess copper on the immune response.},
  author={M. Pocino and L. Heredero Baute and I M Malav{\'e}},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1991},
  volume={16 2},
  pages={249-56}
}
We have studied the influence of the oral administration of excess copper (Cu) on the immune response. With this aim, mice maintained on standard laboratory diet received 50, 100, 200, or 300 ppm of Cu as copper sulfate in the drinking water during 3 to 10 weeks. Inhibition of the proliferative response to concanavalin A was observed in mice exposed to 100 ppm of Cu for 8 weeks and to 200 ppm of Cu for either 3 or 8 weeks. Conversely, a significant increase in the proliferative response to… CONTINUE READING

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