Corpus ID: 45571522

Influence of the new angiotensin converting enzyme inhibitor ramipril on several models of acute inflammation and the adjuvant arthritis in the rat.

@article{Caspritz1986InfluenceOT,
  title={Influence of the new angiotensin converting enzyme inhibitor ramipril on several models of acute inflammation and the adjuvant arthritis in the rat.},
  author={G Caspritz and Hans Georg Dr Alpermann and Rudolf Schleyerbach},
  journal={Arzneimittel-Forschung},
  year={1986},
  volume={36 11},
  pages={
          1605-8
        }
}
  • G Caspritz, Hans Georg Dr Alpermann, Rudolf Schleyerbach
  • Published 1986
  • Medicine
  • Arzneimittel-Forschung
  • Paw oedema in the rat by carrageenin and kaolin partially caused by Hageman factor activation was potentiated by the new angiotensin converting enzyme (ACE) inhibitor 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl-L-alanyl]-(lS,3S,5S)-2- azabicyclo[3.3.0]octane-3-carboxylic acid] (ramipril, Hoe 498) due to its inhibition of kininase II which results in increased bradykinin levels. A dose of 1 microgram ramipril injected into the hind paw of Sprague-Dawley rats concomitantly with, or 1 mg/kg given… CONTINUE READING

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