Influence of the naturally occurring polyamines spermine, spermidine and putrescine on the kinetic properties of acetylcholinesterase. Comparative studies with the acetylcholinesterases from the central nervous system of Manduca sexta and of the synaptic plasma membrane of rat brain.

@article{Peter1979InfluenceOT,
  title={Influence of the naturally occurring polyamines spermine, spermidine and putrescine on the kinetic properties of acetylcholinesterase. Comparative studies with the acetylcholinesterases from the central nervous system of Manduca sexta and of the synaptic plasma membrane of rat brain.},
  author={H. Peter and A. Gies and M. Neumeier and R. Sch{\"a}dler and I. Wegener},
  journal={General pharmacology},
  year={1979},
  volume={10 2},
  pages={
          133-41
        }
}
Abstract 1. Polyamines regulate the activity of the acetylcholinesterase from the central nervous system of the tobacco hornworm Manduca and from the synaptic plasma membrane of rat brain. 2. The acetylcholinesterase from Manduca is more sensitive to polyamines than the acetylcholinesterase from rat brain. 3. Polyamines enhance the affinity of both acetylcholinesterases for the substrate. 4. Both acetylcholinesterases show negative cooperativity, but in presence of physiological concentrations… Expand
8 Citations
Effect of amines and guanidines on peroxidase from maize Scutellum
Abstract The membrane-bound peroxidase activity of excised maize scutellum is inhibited by putrescine, spermidine and spermine and activated by guanidino-acetic acid, guanidino-butyric acid,Expand
Polyamine metabolism and function in brain
  • N. Seiler
  • Medicine, Biology
  • Neurochemistry International
  • 1981
TLDR
The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only for the CNS, but preliminary evidence suggests structural roles in membranes and a modulatory function in certain neuronal systems. Expand
CHAPTER 8 – POLYAMINE METABOLISM AND FUNCTION IN BRAIN
TLDR
The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only for the CNS, but preliminary evidence suggests structural roles in membranes and a modulatory function in certain neuronal systems. Expand
Effect of dietary phospholipids on acetylcholinesterase activity in the rat brain and on phospholipid composition in liver and brain.
  • H. Heger
  • Chemistry, Medicine
  • General pharmacology
  • 1979
TLDR
Dietary phospholipids activate the acetylcholinesterase in the rat brain and increase the substrate affinity of the enzyme, and an oleate-rich diet affects the brain enzyme in the same way. Expand
Dynamic and regional aspects of polyamine metabolism in the brain of trout (Salmo irideus Gibb.).
TLDR
Light microscopic autoradiography revealed a similar regional and cellular distribution of radio-activity deriving from putrescine, spermidine and spermine with preferential labelling of cell rich layers, which can interfere with studies designed to determine dynamic aspects of polyamine metabolism from whole brain analyses. Expand
Reciprocal Regulation of Ornithine Decarboxylase and Choline Kinase Activities by Their Respective Reaction Products in the Developing Rat Cerebellar Cortex
TLDR
Polyamines may play a role in choline utilization during development via their regulation of choline kinase activity, on the one hand, and of acetylcholinesterase activity on the other, and a reciprocal regulation of ornithine decarboxylase activities by their respective reaction products may exist. Expand
Influence of a lipid diet on the amounts of phospholipids and polyamines in rat brain.
TLDR
The amount of phospholipids in rat brain can be enhanced by feeding the rats a diet rich in phospholIPids and this increase is accompanied in either case by a higher level of the polyamines spermine and spermidine. Expand
Cadaverine and putrescine initiate the burial of dead conspecifics by rats
TLDR
The burial of dead conspecifics by rats appears to be under the control of these two polyamines, which contribute to the characteristic odor of decaying tissue. Expand

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THE EFFECT OF SPERMINE AND SPERMIDINE ON THE HYDROLYSIS OF ACETYLTHIOCHOLINE IN THE PRESENCE OF RAT CAUDATE NUCLEUS HOMOGENATE OR ACETYLCHOLINESTERASE FROM ELECTROPHORUS ELECTRICUS
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Combined effect of the polyamine on the substrate and the enzyme showed an inhibition at low and activation at high substrate concentrations, and both polyamines interacted with the substrate, acetylthiocholine, causing an increase in the rate of its non‐enzymatic hydrolysis. Expand
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A role for the polyamines as modulators of synaptic acetylcholinesterase is proposed on the basis of the kinetic results, which suggest an allosteric reaction mechanism. Expand
Inhibition of Na,K-ATPase from chick brain by polyamines.
The amounts of the polyamines putrescine, spermine and spermidine as well as the Na,K-ATPase activity have been determined in the developing chick brain. The amounts of spermine and spermidine perExpand
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TLDR
The inhibitory effect of bisquaternary compounds on erythrocyte membrane-bound acetylcholinesterase (acetylcholine acetyl-hydrolase, EC 3.1.7) was investigated by kinetic methods and yielded the following types of inhibitory mechanisms: d-tubocurarine and gallamine, partially competitive—partially noncompetitive; succinylbischoline, partiallycompetitive-noncompetitive ("mixed inhibition"). Expand
REGIONAL DISTRIBUTION OF PUTRESCINE, SPERMIDINE AND SPERMINE IN RELATION TO THE DISTRIBUTION OF RNA AND DNA IN THE RAT NERVOUS SYSTEM
TLDR
Observations give additional support for the preferential interrelation of spermidine with RNA and spermine with DNA; i.e. for different functional roles of these two narrowly related polycations. Expand
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During the growth in the diluted medium, the phospholipid content of the bacteria changes, and this change is correlated to the increase and decrease in the polyamine content. Expand
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TLDR
Spermine provides a protection against the positively charged parasosaniline and accomplishes a strong potentiation of the action of the negatively charged sodium dodecyl sulphate. Expand
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  • Chemistry, Medicine
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TLDR
It is demonstrated that polyamines may be important regulators of triacylglycerol formation in adipose tissue and the activation of 1,2-diacyl- sn -glycersol acyltransferase by spermine was specific, and other diacyl glycerol-utilizing enzymes were not affected under these conditions. Expand
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