Influence of the glomerular filtration rate on renal clearance of ceftazidime in cystic fibrosis.

@article{Hedman1988InfluenceOT,
  title={Influence of the glomerular filtration rate on renal clearance of ceftazidime in cystic fibrosis.},
  author={Anders Hedman and Y Adan-Abdi and Gunnar Alv{\'a}n and Birgitta Strandvik and A H Arvidsson},
  journal={Clinical pharmacokinetics},
  year={1988},
  volume={15 1},
  pages={57-65}
}
The renal handling of ceftazidime was studied in 8 patients with cystic fibrosis and 10 healthy controls. The renal clearance of ceftazidime (CLRcz) was measured after an intravenous single dose and during low and high plasma concentration steady-state infusions. The glomerular filtration rate (GFR) was simultaneously estimated by inulin clearance (CL inul). The average CLRcz (mean +/- SD) was higher in cystic fibrosis patients (125 +/- 20 ml/min/1.73 m2) than in healthy controls (100 +/- 9 ml… CONTINUE READING

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