Influence of the endothelium on histamine-induced relaxation of rat middle cerebral arteries in vitro.

@article{Benedito1991InfluenceOT,
  title={Influence of the endothelium on histamine-induced relaxation of rat middle cerebral arteries in vitro.},
  author={Sara Benedito and David Prieto and Niels C Berg Nyborg},
  journal={Journal of cardiovascular pharmacology},
  year={1991},
  volume={17 1},
  pages={90-5}
}
Histamine relaxed PGF2 alpha-precontracted rat isolated middle cerebral arteries (ID approximately 230 microns) concentration dependently with a pD2 of 5.31 (EC50: 5 x 10(-6) M). Cimetidine induced a concentration-dependent rightward shift of the histamine concentration-response curve of endothelium-intact arteries. The slope of the Schild plot was… CONTINUE READING