Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youth.

@article{Zhu2005InfluenceOT,
  title={Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youth.},
  author={Haidong Zhu and Xiaoling Wang and Yanbin Dong and Frank A Treiber and Harold Snieder},
  journal={Pharmacogenetics and genomics},
  year={2005},
  volume={15 9},
  pages={669-75}
}
OBJECTIVES To evaluate the impact of the endothelial nitric oxide synthase (eNOS) gene on longitudinal development of blood pressure (BP) and left ventricular mass (LVM) from childhood into early adulthood. METHODS Three polymorphisms including -922A>G, intron 4VNTR, and Glu298Asp of the eNOS gene were investigated. Individual growth-curve modeling and haplotype trend regression analyses were conducted for 579 white and black American youths with 12 assessments over a 15-year period… CONTINUE READING