Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity

@inproceedings{Planeta2013InfluenceOT,
  title={Influence of the dopaminergic system, CREB, and
transcription factor-κB on cocaine neurotoxicity},
  author={C. S. Planeta and L. B. Lepsch and R P Alves and Cristoforo Scavone},
  booktitle={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2013}
}
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter systems, such as the increase of extracellular levels of dopamine and free radicals, and modulation of transcription factors. The aim of… CONTINUE READING

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