Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma

@article{Kuphal2006InfluenceOT,
  title={Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma},
  author={Silke Kuphal and Anja Katrin Bosserhoff},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={248-259}
}
E-cadherin is known to be an important molecule in epithelial–mesenchymal transition (EMT). Malignant transformation of melanocytes frequently attends with loss of E-cadherin expression and induction of expression of mesenchymal molecules like N-cadherin. The switch of the cadherin class is an interesting phenomenon of melanoma cells and in EMT in general. Therefore, we analysed the capacity of E-cadherin to regulate expression of N-cadherin in melanocytic cells. Our experiments revealed that… CONTINUE READING

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