Influence of the cytochrome P4502D6*4 allele on the pharmacokinetics of controlled-release metoprolol

@article{Koytchev1998InfluenceOT,
  title={Influence of the cytochrome P4502D6*4 allele on the pharmacokinetics of controlled-release metoprolol},
  author={Rossen Koytchev and R Giesbert Alken and Vitan Dakov Vlahov and Valentin Kirkov and Radka Kaneva and Ursula Thyroff-Friesinger and Edelgard Rehak},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={469-474}
}
Aim: The aim of the present paper was to compare the pharmacokinetics of metoprolol in homozygous Caucasian volunteers for the wild-type CYP2D6 allele (CYP2D6*1/CYP2D6*1) and heterozygous (CYP2D6*1/CYP2D6*4) Caucasians. Methods: Thirty-six unrelated healthy male Caucasians were screened for two of the most frequently occurring mutant alleles (CYP2D6*3 and CYP2D6*4) using polymerase chain reaction (PCR). Twenty-four volunteers with a genotype suggesting a rapid hydroxylator phenotype were… CONTINUE READING

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