Influence of the composition of monoacyl phosphatidylcholine based microemulsions on the dermal delivery of flufenamic acid.

@article{Hoppel2014InfluenceOT,
  title={Influence of the composition of monoacyl phosphatidylcholine based microemulsions on the dermal delivery of flufenamic acid.},
  author={Magdalena Hoppel and Hanna Ettl and Evelyn Holper and Claudia Valenta},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={475 1-2},
  pages={156-62}
}
Although microemulsions are one of the most promising dermal carrier systems, their clinical use is limited due to their skin irritation potential. Therefore, microemulsions based on naturally derived monoacyl phosphatidylcholine (MAPL) were developed. The influence of the water, oil and surfactant content on dermal delivery of flufenamic acid was systematically investigated for the first time. A water-rich microemulsion led to significantly higher in vitro skin penetration of flufenamic acid… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Investigations into the formation and characterization of phospholipid microemulsions. I. Pseudo-ternary phase diagrams of systems containing water–lecithin–alcohol-isopropyl myristate

  • R. Aboofazeli, M. Lawrence
  • Int. J. Pharm
  • 1993
Highly Influential
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