Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women.

@article{Worda2003InfluenceOT,
  title={Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women.},
  author={Christof Worda and Michael O. Sator and Christian Schneeberger and T Jantschev and Kathrin Ferlitsch and Johannes C. Huber},
  journal={Human reproduction},
  year={2003},
  volume={18 2},
  pages={262-6}
}
BACKGROUND Catechol-O-methyltransferase (COMT) is the principal enzyme in the conjugation pathway for hydroxylated estrogens. We hypothesize that blood 17beta-estradiol (E(2)) and estrone (E(1)) levels in postmenopausal women receiving an oral E(2) preparation are dependent on the enzyme activity of COMT. METHODS To determine the influence of this enzyme on E(2) serum levels three groups of 12 selected from 159 healthy normotensive postmenopausal women were selected according to their codon… CONTINUE READING
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