Influence of the antileukemic and anti-human immunodeficiency virus agent avarol on selected immune responses in vitro and in vivo.

@article{Mller1987InfluenceOT,
  title={Influence of the antileukemic and anti-human immunodeficiency virus agent avarol on selected immune responses in vitro and in vivo.},
  author={Walter E. M{\"u}ller and C Sobel and B{\"a}rbel Diehl-seifert and Armin Maidhof and Heinz C. Schr{\"o}der},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 9},
  pages={1489-94}
}
The effect of the antileukemic and anti-HIV agent avarol on the lymphoid system was studied both in vitro and in vivo. Radioactively labelled avarol ([3H]-dihydroavarol) was found to accumulate in vitro in the cytoplasmic compartment primarily of T-lymphocytes and not of B-lymphocytes. Avarol increased significantly the IgG and IgM production by cultures of human lymphoid cells (unseparated) in vitro and slightly the number of plaque forming cells in vivo in spleen of mice. Moreover, a… CONTINUE READING

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