Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides.

@article{Wieprecht1997InfluenceOT,
  title={Influence of the angle subtended by the positively charged helix face on the membrane activity of amphipathic, antibacterial peptides.},
  author={Torsten Wieprecht and Margitta E Dathe and Richard M Epand and Michael Beyermann and Eberhard Krause and Walter Lee Maloy and David L MacDonald and M. Bienert},
  journal={Biochemistry},
  year={1997},
  volume={36 42},
  pages={12869-80}
}
To investigate the influence of the angle subtended by the positively charged helix face on membrane activity, six amphipathic alpha-helical peptides with angles between 80 degrees and 180 degrees, but with retained hydrophobicity, hydrophobic moment, and positive overall charge, were designed starting from the sequence of the antibacterial peptide magainin… CONTINUE READING