Influence of the OGG1 Ser326Cys polymorphism on oxidatively damaged DNA and repair activity.

Abstract

Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the OGG1 Ser326Cys polymorphism on the level and repair of oxidatively damaged DNA in mononuclear blood cells (MNBC) by means of the comet assay. We collected blood samples from 1,019 healthy… (More)
DOI: 10.1016/j.freeradbiomed.2011.09.038

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