Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.

@article{Evans1998InfluenceOT,
  title={Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.},
  author={Kenneth R. Evans and Luciano Passador and Ramakrishnan Srikumar and Edward P. K. Tsang and Jon Nezezon and Keith Poole},
  journal={Journal of bacteriology},
  year={1998},
  volume={180 20},
  pages={5443-7}
}
Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation… CONTINUE READING