Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes.

@article{Batchelor2017InfluenceOT,
  title={Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes.},
  author={Lucinda K Batchelor and Emilia Păunescu and Myl{\`e}ne Soudani and Rosario Scopelliti and Paul J Dyson},
  journal={Inorganic chemistry},
  year={2017},
  volume={56 16},
  pages={
          9617-9633
        }
}
Dinuclear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinuclear ruthenium(II) p-cymene and gold(I) complexes, in which the length of the connecting poly(ethylene glycol) chain has been systematically modified. The impact of the multinuclearity, lipophilicity, and linker length on the antiproliferative activity of the compounds on tumorigenic (A2780 and… CONTINUE READING