Influence of the H-2u haplotype on immune function in F1 hybrid mice. I. Antigen presentation.

@article{Fritz1985InfluenceOT,
  title={Influence of the H-2u haplotype on immune function in F1 hybrid mice. I. Antigen presentation.},
  author={Robert B. Fritz and Marianne J. Skeen and H. Kirk Ziegler},
  journal={Journal of immunology},
  year={1985},
  volume={134 6},
  pages={3574-9}
}
Previously, we reported that myelin basic protein (MBP) peptide 1-37 contains an encephalitogenic epitope for PL/J mice, and MBP peptide 89-169 is encephalitogenic for SJL/J mice. (SJPL)F1 hybrid mice do not respond to immunization with these peptides in a co-dominant manner because the encephalitogenic response to peptide 1-37 dominates. To examine this phenomenon more closely, we tested the ability of MBP-primed parental or F1 T cells to respond to MBP or MBP peptides in the context of PL… CONTINUE READING

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