Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology

@article{Martino2015InfluenceOT,
  title={Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology},
  author={Tami A Martino and Martin E. Young},
  journal={Journal of Biological Rhythms},
  year={2015},
  volume={30},
  pages={183 - 205}
}
Cardiac function and dysfunction exhibit striking time-of-day-dependent oscillations. Disturbances in both daily rhythms and sleep are associated with increased risk of heart disease, adverse cardiovascular events, and worsening outcomes. For example, the importance of maintaining normal daily rhythms is highlighted by epidemiologic observations that night shift workers present with increased incidence of cardiovascular disease. Rhythmicity in cardiac processes is mediated by a complex… 
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