Influence of the A and B subunits of cholera toxin (CT) and Escherichia coli toxin (LT) on TNF-alpha release from macrophages.

@article{Domingos2009InfluenceOT,
  title={Influence of the A and B subunits of cholera toxin (CT) and Escherichia coli toxin (LT) on TNF-alpha release from macrophages.},
  author={Marta de Oliveira Domingos and Roberto G. Andrade and K{\'a}tia Cristina Barbaro and Monamaris Marques Borges and David J Lewis and Roger Randal Charles New},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2009},
  volume={53 5},
  pages={570-7}
}
In this study an in vitro model was developed with the aim of investigating the modulatory effect of cholera toxin (CT) and its counterpart the heat labile toxin of Escherichia coli (LT) on TNF-alpha release induced by murine macrophages and primary human monocytes. Previous studies have demonstrated that the enzymatic activity of CT and LT molecules can inhibit TNF-alpha release by macrophages. The results obtained in this study showed that CT and LT are both, in a dose dependent manner, able… CONTINUE READING