Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer.

@article{Geiser2003InfluenceOS,
  title={Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer.},
  author={Marianne Geiser and Samuel Schurch and Peter Gehr},
  journal={Journal of applied physiology},
  year={2003},
  volume={94 5},
  pages={1793-801}
}
Inhaled and deposited spherical particles, 1-6 micrometer in diameter and of differing surface chemistry and topography, were studied in hamster intrapulmonary conducting airways and alveoli by electron microscopy. Polystyrene and Teflon particles, as well as puffball spores, were found submersed in the aqueous lining layer and adjacent to epithelial cells. The extent of particle immersion promoted by a surfactant film was assessed in a "floating-drop-surface balance" by light microscopy… CONTINUE READING

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