Influence of surface characteristics of modified glass beads as model carriers in dry powder inhalers (DPIs) on the aerosolization performance.

@article{Zellnitz2015InfluenceOS,
  title={Influence of surface characteristics of modified glass beads as model carriers in dry powder inhalers (DPIs) on the aerosolization performance.},
  author={Sarah Zellnitz and Hartmuth Schroettner and Nora Anne Urbanetz},
  journal={Drug development and industrial pharmacy},
  year={2015},
  volume={41 10},
  pages={1710-7}
}
The aim of this work is to investigate the effect of surface characteristics (surface roughness and specific surface area) of surface-modified glass beads as model carriers in dry powder inhalers (DPIs) on the aerosolization, and thus, the in vitro respirable fraction often referred to as fine particle fraction (FPF). By processing glass beads in a ball mill with different grinding materials (quartz and tungsten carbide) and varying grinding time (4 h and 8 h), and by plasma etching for 1 min… CONTINUE READING

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