Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine.

@article{Fenster1997InfluenceOS,
  title={Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine.},
  author={Catherine P. Fenster and Michael Rains and Brett D. Noerager and Michael W. Quick and Robin A. J. Lester},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 15},
  pages={5747-59}
}
The influence of alpha and beta subunits on the properties of nicotine-induced activation and desensitization of neuronal nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes was examined. Receptors containing alpha4 subunits were more sensitive to activation by nicotine than alpha3-containing receptors. At low concentrations of nicotine, nAChRs containing beta2 subunits reached near-maximal desensitization more rapidly than beta4-containing receptors. The concentration of… CONTINUE READING
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Sustained nicotine exposure differentially affects a3b2 and a4b2 neuronal nicotinic receptors expressed in Xenopus oocytes

  • Y-N Hsu, J Amin, DS Weiss, L Wecker
  • J Neurochem
  • 1995
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