Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids.

  title={Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids.},
  author={Scott M. Grundy},
  journal={The American journal of clinical nutrition},
  volume={60 6 Suppl},
  • S. Grundy
  • Published 1 December 1994
  • Biology
  • The American journal of clinical nutrition
Stearic acid is a long-chain saturated fatty acid. However, in contrast with other saturated fatty acids, stearic acid apparently does not raise serum cholesterol concentrations. Studies carried out three decades ago provided strong suggestive evidence that this was the case. More recent investigations that specifically compared stearic acid with other fatty acids in human studies have confirmed that stearic acid is not hypercholesterolemic. Stearic acid was shown not to raise low-density… 

Dietary stearic acid reduces cholesterol absorption and increases endogenous cholesterol excretion in hamsters fed cereal-based diets.

The data suggest that reduced plasma cholesterol concentration in hamsters fed high 18:0 diets may be influenced by reduced cholesterol absorption and increased excretion of endogenous cholesterol.

Cholesterolaemic effect of palmitic acid in relation to other dietary fatty acids.

The data indicated that high levels of palmitic acid were not hypercholesterolaemic if intake of linoleic acid was greater than 4.5% of energy when the diet contained trans fatty acids.

Nutrient Metabolism Dietary Stearic Acid Reduces Cholesterol Absorption and Increases Endogenous Cholesterol Excretion in Hamsters Fed Cereal-Based Diets 1 , 2

The data suggest that reduced plasma cholesterol concentration in hamsters fed high 18:0 diets may be influenced by reduced cholesterol absorption and increased excretion of endogenous cholesterol.

Individual fattyacideffectson plasmalipidsand lipoproteins: human ,2

This review summarizes and critically evaluates the current understanding of the effects of specific fatty acids on plasma lipids and lipoproteins and shows that monounsaturated fatty acids appear to exert a neutral effect or to be mildly hypocholesterolemic effect.

Exchanging partially hydrogenated fat for palmitic acid in the diet increases LDL-cholesterol and endogenous cholesterol synthesis in normocholesterolemic women

Comparisons of the effects of trans to saturated fatty acids using stable isotope methodology are compared to establish if the mechanism of increase in TC and LDL-cholesterol is due to the increase in the rate of endogenous synthesis of cholesterol.

Reduction in cholesterol absorption is enhanced by stearate-enriched plant sterol esters in hamsters.

It is demonstrated that BT and SA are more effective than SO in reducing cholesterol absorption, liver cholesterol, and plasma non-HDL cholesterol concentration, suggesting that cardioprotective benefits can be achieved by consuming stearate-enriched plant sterol esters.

The role of stereospecific saturated fatty acid positions on lipid nutrition.

  • E. Decker
  • Biology, Medicine
    Nutrition reviews
  • 1996
Differences in stereospecific fatty acid location should be an important consideration in the design and interpretation of lipid nutrition studies and in the production of specialty food products.

Reduction of dietary saturated fatty acids correlates with increased plasma lecithin cholesterol acyltransferase activity in humans

Results are consistent with a negative effect of SFA on reverse cholesterol transport, as well as a significant increase of HDL-C, while plasma apo A-I concentration and LCAT activity decreased.

A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males

Results from this study indicate that stearic acid (19 g/day) in the diet has beneficial effects on thrombogenic and atherogenic risk factors in males, and the food industry might wish to consider the enrichment of foods with staric acid in place of palmitic acid and trans fatty acids.



Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins.

Lauric acid raises total and LDL cholesterol concentrations compared with oleic acid, but is not as potent for increasing cholesterol concentrations as is palmitic acid.

Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans.

Findings show that 7.7% of energy (mean, 24 g/day) of trans fatty acids in the diet significantly lowered HDL cholesterol and raised LDL cholesterol relative to linoleic acid.

Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men.

The effects of beef tallow and cocoa butter, two fats with a high stearic acid content (C18:0), on serum lipid and lipoprotein concentrations were compared with the effects of butter fat and olive

Comparison of monounsaturated fatty acids and carbohydrates for reducing raised levels of plasma cholesterol in man.

A solid-food diet rich in monounsaturated fatty acids is equivalent to a low-fat, high-carbohydrate diet for cholesterol lowering but does not reduce the HDL-cholesterol level.

Stearic acid, clotting, and thrombosis.

  • J. Hoak
  • Medicine
    The American journal of clinical nutrition
  • 1994
If a thrombogenic effect of long-chain saturated fatty acids exists in humans, it is most likely to occur as an aberration of fatty acid transport in which the FFA-albumin molar ratio exceeds 2 either as a result of very high plasma FFA concentrations from lipid mobilization or a low concentration of albumin in the blood as found in disease states such as the nephrotic syndrome.

Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects.

The effect of trans fatty acids on the serum lipoprotein profile is at least as unfavorable as that of the cholesterol-raising saturated fatty acids, because they not only raise LDL cholesterol levels but also lower HDL cholesterol levels.

Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia.

  • S. Grundy
  • Medicine, Biology
    The Journal of clinical investigation
  • 1975
Changes in the metabolism of cholesterol, bile acids, and triglycerides in the patients of this study suggests that polyunsaturated fats may cause a lowering of cholesterol through multiple mechanisms, and it seems unlikely that a single action can explain all the effects of these fats on the plasma lipids.