Influence of steady-state alterations in acid-base equilibrium on the fate of administered bicarbonate in the dog.

@article{Adrogu1983InfluenceOS,
  title={Influence of steady-state alterations in acid-base equilibrium on the fate of administered bicarbonate in the dog.},
  author={Horacio J. Adrogu{\'e} and Jeffrey M. Brensilver and Jordan Cohen and Nicolaos E. Madias},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={71 4},
  pages={867-83}
}
Previous workers have shown that metabolic acidosis increases the apparent space through which administered bicarbonate is distributed. This finding has been ascribed to the accompanying acidemia and to the consequent availability of a large quantity of hydrogen ion that accumulates on nonbicarbonate tissue buffers during the development of acidosis. To test this hypothesis, bicarbonate space was measured in dogs with a broad range of steady-state plasma [HCO-3] in association with alkalemia as… CONTINUE READING
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