Influence of spasmolytic analgesics on motility of sphincter of oddi

  title={Influence of spasmolytic analgesics on motility of sphincter of oddi},
  author={Gerald Brandst{\"a}tter and Stefan Schinzel and Herbert Wurzer},
  journal={Digestive Diseases and Sciences},
The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg;N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal… 

Effects of narcotic analgesic drugs on human Oddi's sphincter motility.

Findings indicate that Oddi's sphincter manometry via choledochoscope is a practical and new way to study the dynamics of Oddi' s spHincter and morphine could increase BPOS, SOF and SOCA and increase the level of CBDP.

Nitroester drug's effects and their antagonistic effects against morphine on human sphincter of Oddi motility.

The regular dose of GTN, ISDN and PTN showed inhibitory effect on So motility, morphine showed excitatory effect on SO whileGTN, Isosorbide dinitrate and PTn could antagonize the effect of morphine.

A Synthetic Prostaglandin E1 Analog, Alprostadil Alfadex, Relaxes Sphincter of Oddi in Humans

A synthetic PGE1 analog, alprostadil alfadex, effectively inhibits motility of the human SO, and may be of clinical application as a SO-relaxing agent.

Airway Smooth Muscle Relaxations Induced by Dipyrone

Inhibition of the release of intracellular Ca2+ may play a role in the smooth muscle relaxing effect of dipyrone.

Effects of dipyrone on the digestive tract

  • E. F. CollaresL. Troncon
  • Medicine, Biology
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2019
In rats, in contrast to nonselective non-hormonal anti-inflammatory drugs, dipyrone protects the gastric mucosa attenuating the development of gastric ulcers induced by a number of agents.

Dipyrone improves small airway function in asthmatic patients with moderate obstruction.

Dipyrone had a significant effect leading to an improved small airway function in asthmatic patients with moderate airway obstruction, confirming the recent in vitro findings.

The feasibility and reliability of using circular electrode for sphincter of Oddi electromyography in anaesthetised rabbits

  • F. ChenJing Chen Z-H Li
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2009
Electromyography of sphincter of Oddi (SO) using a circular electrode (CE) has advantages of easy fixation, accurate localisation, broad applicability and ease of achieving satisfactory outcomes without trauma, compared with the NE.

Adverse Effects of Diclofenac after Cesarean Section: A Case Report

A 27-year-old nullipara, 38 weeks pregnant, was admitted for elective cesarean section under spinal anesthesia with diagnosis of Oddi spasm, and the intensity of pain was decreased significantly.

Effects of Spascupreel versus hyoscine butylbromide for gastrointestinal cramps in children

The effectiveness and tolerability of the homeopathic preparation Spascupreel was compared with that of hyoscine butylbromide treatment in children <12 years of age.

Hyoscine butylbromide – a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures

These clinical results of rapid action and beneficial efficacy combined with good tolerability support the use of HBB in a range of indications related to acute abdominal spasm, in labour and palliative care and for supporting diagnostic and therapeutic abdominal procedures, where spasm may be a problem.



Effects of buprenorphine on motor activity of the sphincter of Oddi in man

Buprenorphine has no morphine-like effect on SO motility, but it does act like a partial antagonist of morphine in reducing the amplitude of SO contraction waves.

Effect of N-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP--a manometric study.

It is demonstrated that N-butylscopolamine inhibits contractions of the sphincter of Oddi, and may thus facilitate the intubation of the papilla, in patients undergoing routine diagnostic ERCP.

The effect of midazolam on motility of the sphincter of Oddi in human subjects.

These results suggest that in patients with normal manometric findings midazolam does not interfere with SO recording, and may be beneficial for sedation in upper GI endoscopy.

Effect of glyceryl trinitrate on the sphincter of Oddi motility and baseline pressure.

GTN proved to be useful as premedication for endoscopic examinations, particularly for the removal of small and medium size common bile duct stones through the intact papilla, and should be taken into account for the treatment of biliary colic.

Effect of somatostatin analog octreotide on human sphincter of Oddi

The effect of the long-acting somatostatin analog octreotide on the sphincter of Oddi was investigated in seven subjects referred for endoscopic sphincter of Oddi manometry. Six patients had

Sphincter of oddi manometry

In chronic alcohol abusers with no pancreatic disease, secretin was found to induce a paradoxical spasmodic response in the sphincter of Oddi instead of the relaxation observed in controls, whereas cerulein had a normal relaxing effect on the SO.

Intravenous indomethacin in biliary pain. A clinical investigation with metamizole as the control.

Intravenous indomethacin is a recommendable alternative for intravenous metamizole in the treatment of biliary pain and the risks for agranulocytosis appear to be lesser than those associated with metamIZole.

Effect of glucagon on sphincter of Oddi motor activity.

Data of the present study would not support the use of glucagon whenever a spasmolytic effect on the SO is looked for, and appeared to induce any relevant variation of SO resting pressure nor frequency, amplitude and duration of phasic contractions.

Effect of modern analgesic drugs (tramadol, pentazocine, and buprenorphine) on the bile duct sphincter in man.

It is considered that pentazocine is not the premedication of first choice for endoscopic procedures involving the sphincter of Oddi and should also be avoided in patients with pancreatic and biliary disorders.

Distension of the gall bladder inhibits sphincter of Oddi motility in humans.

A local reflex between the gall bladder and the sphincter of Oddi that might be important in the regulation of the pressure within the bile ducts and flow across the spHincter is suggested.