Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content.

@article{Mostafa1990InfluenceOS,
  title={Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content.},
  author={Mostafa Mostafa and Salah A Sheweita and N M Abdel-Moneam},
  journal={Environmental research},
  year={1990},
  volume={52 1},
  pages={77-82}
}
The metabolism of benzo[a]pyrene is mediated by the mixed function oxidase system including the cytochrome P450-dependent aryl hydrocarbon hydroxylase. The data of the present study revealed the ability of various commonly used anti-inflammatory drugs to alter the activity of this enzyme system, where all the tested drugs, namely phenyl butazone, ketoprofen… CONTINUE READING