Influence of some GABAergic agents on nitrazepam-induced sleep in the domestic fowl (Gallus domesticus).

@article{Wambebe1983InfluenceOS,
  title={Influence of some GABAergic agents on nitrazepam-induced sleep in the domestic fowl (Gallus domesticus).},
  author={Charles O Wambebe},
  journal={Japanese journal of pharmacology},
  year={1983},
  volume={33 6},
  pages={
          1111-8
        }
}
  • C. Wambebe
  • Published 1 December 1983
  • Chemistry, Medicine
  • Japanese journal of pharmacology
The effects of gamma amino butyric acid (GABA), bicuculline and amino-oxyacetic acid (AOAA) on nitrazepam-induced sleep were studied in young chicks. GABA (200-3200 mg/kg) induced a marked sedation in young chicks. It also potentiated nitrazepam (1.6 mg/kg)-induced sleep. Bicuculline (1.25-5.00 mg/kg) effectively antagonized nitrazepam-induced sleep. In addition, it effectively antagonized GABA (1600 mg/kg)-induced potentiation of nitrazepam sleep. AOAA (2.5-7.5 mg/kg) delayed the onset of… Expand
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