Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations.

@article{Donovan2010InfluenceOS,
  title={Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations.},
  author={Martin J Donovan and Hugh D C Smyth},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={402 1-2},
  pages={1-9}
}
The objective of this study was to determine the effect of both carrier particle size and surface roughness on the aerosol performance of dry powder formulations. Two morphologically distinct grades of lactose, anhydrous (AN) and granulated (GR), were fractionated into 11 discreet sizes up to 300μm, and separately employed as carriers in 2% (w/w) budesonide blends. In vitro deposition studies were performed at 60Lmin(-1) with an Aerolizer(®) DPI. It was found that large carriers can improve… CONTINUE READING
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