Influence of site-directed modifications on the formation of iron cores in ferritin.

@article{Wade1991InfluenceOS,
  title={Influence of site-directed modifications on the formation of iron cores in ferritin.},
  author={Vanessa J. Wade and Sonia Levi and P. Arosio and Amyra Treffry and Pauline M. Harrison and Stephen Mann},
  journal={Journal of molecular biology},
  year={1991},
  volume={221 4},
  pages={1443-52}
}
The structure and crystal chemical properties of iron cores of reconstituted recombinant human ferritins and their site-directed variants have been studied by transmission electron microscopy and electron diffraction. The kinetics of Fe uptake have been compared spectrophotometrically. Recombinant L and H-chain ferritins, and recombinant H-chain variants incorporating modifications in the threefold (Asp131----His or Glu134----Ala) and fourfold (Leu169----Arg) channels, at the partially buried… CONTINUE READING

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