Influence of single-stranded DNA-binding protein on recA induction in Escherichia coli.

  title={Influence of single-stranded DNA-binding protein on recA induction in Escherichia coli.},
  author={R. R. Meyer and D. Voegele and S. M. Ruben and D. Rein and J. Trela},
  journal={Mutation research},
  volume={94 2},
  • R. R. Meyer, D. Voegele, +2 authors J. Trela
  • Published 1982
  • Biology, Medicine
  • Mutation research
  • Two ssb mutants of Escherichia coli, which carry a lesion in the single-strand DNA-binding protein (SSB), are sensitive to UV-irradiation. We have investigated the influence of SSB on the "SOS" repair pathway by examining the levels of recA protein synthesis. These strains fail to induce normal levels of recA protein after treatment with nalidixic acid or ultraviolet light. The level of recA protein synthesis in wild-type cells is about three times greater than ssb cells. This deficiency in ssb… CONTINUE READING
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