Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.

@article{Psotov2002InfluenceOS,
  title={Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.},
  author={Jitka Psotov{\'a} and S{\'a}rka Chlopc{\'i}kov{\'a} and Frantisek Grambal and Vil{\'i}m {\vS}im{\'a}nek and Jitka Ulrichov{\'a}},
  journal={Phytotherapy research : PTR},
  year={2002},
  volume={16 Suppl 1},
  pages={S63-7}
}
Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron-dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more potent than either silymarin or its three constituents, whose cytoprotectivity was comparable. The radical scavenging activity of the compounds was investigated using a DPPH colour reduction assay and… CONTINUE READING