Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate.

Abstract

A new technique to quantify the effects of shear intensity and total shear on the homogeneity, flowability and bulk density of a lubricated free-flowing pharmaceutical blend and on properties of resulting tablets is presented. A modified Couette cylindrical cell with uniformly spaced pins is used to create a uniform shear environment. The range of lubricant concentrations explored is 0-2% (on a mass basis). Sheared blends are used to produce tablets in the Presster (a simulator of an actual tablet press), allowing us to correlate the shear history of the blend (shear intensity and total shear) with the crushing hardness of tablets. The results show that the larger the total shear, the more homogeneous the blend. Bulk density increases with total shear until reaching a distinctive plateau. Results also indicate that high total shear affects the blend flow properties. For tablets, crushing hardness decreases as concentration of lubricant and total shear increase. Interestingly, and unexpectedly, under constant total shear, shear intensity affects the crushing hardness of tablets only slightly.

Statistics

01002002008200920102011201220132014201520162017
Citations per Year

216 Citations

Semantic Scholar estimates that this publication has 216 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Mehrotra2007InfluenceOS, title={Influence of shear intensity and total shear on properties of blends and tablets of lactose and cellulose lubricated with magnesium stearate.}, author={Amit Mehrotra and Marcos Llus{\'a} and Abdul Mobeen N Faqih and Michael Levin and Fernando J. Muzzio}, journal={International journal of pharmaceutics}, year={2007}, volume={336 2}, pages={284-91} }